Organo-Metalloid Compounds
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- (139)
- (2)
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- (251)
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- (1)
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- (9)
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Filtered Search Results
Medchemexpress LLC PS-1145 | 431898-65-6 | 99.7% | 322.75 | 1 MG
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PS-1145 | 431898-65-6 | 99.7% | 322.75 | 1 MG
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Accela Chembio Inc 2 | 2'-bis(trifluoromethyl)benzidine | 100g | 341-58-2 | MFCD00190155 | 97+% | Shelf Life: 1260 Days | Light Sensitive
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2 | 2'-bis(trifluoromethyl)benzidine | 100g | 341-58-2 | MFCD00190155 | 97+% | Shelf Life: 1260 Days | Light Sensitive
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Medchemexpress LLC AK-778-XXMU | 1227045-76-2 | 99.9% | C22H17ClN2O3 | 1 ML
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AK-778-XXMU is a potent DNA binding inhibitor 2 (ID2) antagonist with a KD of 129 nM. It can inhibit cell migration and invasion of glioma cell lines, induce apoptosis, and exhibits significant cancer-suppressing potency. The compound acts by inhibiting the ID2-KDR signaling axis, leading to the down-regulation of angiogenic factors (VEGFA) and invasion-related proteins (MMP2/9), and the up-regulation of the tumor suppressor factor (PTEN). It is suitable for the study of glioma.
- Potent ID2 antagonist with a KD of 129 nM
- Inhibits cell migration and invasion in glioma cell lines
- Induces apoptosis
- Exhibits significant cancer-suppressing potency
- Down-regulates angiogenic factors (VEGFA)
- Down-regulates invasion-related proteins (MMP2/9)
- Up-regulates tumor suppressor factor (PTEN)
- Inhibits tumor growth in U87 glioma xenograft mice model
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Medchemexpress LLC Ps-1145 | 431898-65-6 | MFCD08705411 | 99.9% | 322.75 | C17H11ClN4O | 10 MG
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PS-1145 is a small-molecule inhibitor of IκB kinase (IKK) used in research to block NF-κB signaling and induce apoptosis in cell models. It is supplied as a powder with documented solubility and storage recommendations for experimental use.
- Potent IKK inhibitor with IC50 of 88 nM.
- High chemical purity (99.88%).
- Provided as a powder for convenient handling and formulation.
- Soluble in DMSO at 20.83 mg/mL; multiple in vitro formulations available.
- Stable under recommended storage conditions for long-term use.
- Suitable for in vitro studies of NF-κB signaling and apoptosis pathways.
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Medchemexpress LLC AK-778-XXMU | 1227045-76-2 | 99.9% | C22H17ClN2O3 | 50 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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AK-778-XXMU is a potent DNA binding inhibitor 2 (ID2) antagonist with a KD of 129 nM, used for the study of glioma. It inhibits the ID2-KDR signaling axis, leading to the downregulation of downstream angiogenic factors and invasion-related proteins, and the upregulation of the tumor suppressor factor PTEN. This compound demonstrates significant cancer-suppressing potency by inhibiting cell migration and invasion of glioma cell lines and inducing apoptosis.
- Potent ID2 antagonist with a KD of 129 nM
- Inhibits cell migration and invasion of glioma cell lines
- Induces apoptosis
- Inhibits ID2-KDR signaling axis
- Downregulates angiogenic factors (VEGFA) and invasion-related proteins (MMP2/9)
- Upregulates tumor suppressor factor (PTEN)
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Medchemexpress LLC PS-1145 | 431898-65-6 | 99.67% | 322.75 | 25 MG
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PS-1145 is an IκB kinase (IKK) inhibitor with an IC50 of 88 nM.
- Blocks TNFα-induced NF-κB activation in a dose- and time-dependent manner in MM cells through inhibition of IκBα phosphorylation.
- Dexamethasone enhances the blockade of NF-κB activation by the product.
- Blocks the protective effect of IL-6 against Dexamethasone-induced apoptosis.
- Inhibits TNFα-induced intracellular adhesion molecule (ICAM)-1 expression.
- Inhibits both IL-6 secretion from bone marrow stromal cells (BMSCs) triggered by MM cell adhesion and proliferation of MM cells adherent to BMSCs.
- Administration results in a significant decrease in serum levels of three cytokines.
- Blocks hypothalamic inflammation induced by IL-4.
- Decreases IL-1β mRNA content.
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Medchemexpress LLC PS-1145 | 431898-65-6 | 99.67% | 322.75 | 100 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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PS-1145 is an IκB kinase (IKK) inhibitor with an IC50 of 88 nM, functioning to block TNFα-induced NF-κB activation by inhibiting IκBα phosphorylation in multiple myeloma (MM) cells. This inhibition is observed in a dose- and time-dependent manner. It also enhances the blockade of NF-κB activation when combined with Dexamethasone, and can inhibit the protective effect of IL-6 against Dexamethasone-induced apoptosis.
- Potent inhibitor of IKK activity.
- Blocks phosphorylation of IκBα.
- Inhibits TNFα-induced NF-κB activation.
- Reduces TNFα-induced intracellular adhesion molecule (ICAM)-1 expression.
- Demonstrates antiproliferative activity against certain human cells.
- Decreases serum levels of specific cytokines in vivo.
- Can block inflammation-induced weight gain during high-fat feeding.
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Medchemexpress LLC AK-778-XXMU | 1227045-76-2 | 99.9% | C22H17ClN2O3 | 25 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
Small and/or specialty supplier based on Federal laws and SBA requirements.
Learn More
AK-778-XXMU is a potent DNA binding inhibitor 2 (ID2) antagonist with a KD of 129 nM. It inhibits the ID2-KDR signaling axis, leading to the down-regulation of downstream angiogenic factors (VEGFA) and invasion-related proteins (MMP2/9), while up-regulating the tumor suppressor factor (PTEN). It can inhibit cell migration and invasion of glioma cell lines, induce apoptosis, and demonstrates significant cancer-suppressing potency. This compound is used for the study of glioma.
- Potent DNA binding inhibitor 2 (ID2) antagonist
- Inhibits cell migration and invasion of glioma cell lines
- Induces apoptosis
- Demonstrates significant cancer-suppressing potency
- Inhibits ID2-KDR signaling axis
- Down-regulates angiogenic factors (VEGFA) and invasion-related proteins (MMP2/9)
- Up-regulates tumor suppressor factor (PTEN)
- Suitable for the study of glioma
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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eMolecules 1503378-02-6 | ChemScene | 7-Methoxy-23-dihydrobenzofuran-3-carboxylic acid | 100mg | 712840997 | CS-0438340 | MFCD26129953 | 194.186 | C10H10O4
Ambeed | 4-Bromo-2-(26-dioxopiperidin-3-yl)isoindoline-13-dione | 250mg | 633418021 | A1215363 | 2093536-12-8 | 337.129 | C13H9BrN2O4
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(OC)c1ccccc1 | 10g | 525102076](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC2039302.JPG-250.jpg)
eMolecules 3027-21-2 | Dimethoxy(methyl)(phenyl)silane | Ambeed | MFCD00008343 | 182.294 | C9H14O2Si | 98 | CO[Si](C)(OC)c1ccccc1 | 10g | 525102076
Ambeed | (S)-2-((2R3R)-3-((S)-1-((3R4S5S)-4-((S)-N3-Dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanamido)-3-phenylpropanoic acid | 2mg | 491171472 | A309085 | 745017-94-1 | MFCD25976742 | 731.976 | C39H65N5O8
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![eMolecules 1221343-14-1 | Ambeed | 1-Hydroxy-13-dihydrobenzo[c][12]oxaborole-6-carboxylic acid | 250mg | 539143562 | A885286 | MFCD20527893 | 177.95 | C8H7BO4](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502485451.JPG-250.jpg)
eMolecules 1221343-14-1 | Ambeed | 1-Hydroxy-13-dihydrobenzo[c][12]oxaborole-6-carboxylic acid | 250mg | 539143562 | A885286 | MFCD20527893 | 177.95 | C8H7BO4
Ambeed | tert-Butyl 3-(4455-tetramethyl-132-dioxaborolan-2-yl)propanoate | 1g | 717677379 | A113485 | 134892-19-6 | MFCD10700151 | 256.150 | C13H25BO4
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Apexbio Technology LLC PS-1145 431898-65-6 25mg
Small and Specialty Supplier Partner
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PS-1145 (CAS 431898-65-6) is a selective inhibitor of I B kinase (IKK) with an IC50 of 88 nM IKK is a critical component of the upstream NF- B signaling pathway regulating cellular responses to inflammation In vitro studies have demonstrated that PS-1145 blocks TNF -induced NF- B activation in multiple myeloma (MM) cells in a dose- and time-dependent manner increases I B protein levels suppresses IL-6-mediated anti-apoptotic effects and inhibits expression of ICAM-1 Additionally PS-1145 reduces IL-6 secretion from bone marrow stromal cells (BMSCs) and partially limits MM cell proliferation In vivo PS-1145 has been shown to induce apoptosis in DMBA-induced skin tumors in rats by inhibiting NF- B and VEGF activity The compound remains in the preclinical research stage
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![eMolecules 280752-78-5 | (6-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol | MFCD10699559 | 250mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502138417.JPG-250.jpg)
eMolecules 280752-78-5 | (6-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol | MFCD10699559 | 250mg
Medchem Express | Delphinidin 3-glucoside (chloride) | 1mg | 632433155 | HY-108052 | 6906-38-3 | MFCD01762899 | 500.840 | C21H21ClO12
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eMolecules 887375-37-3 | 4-(5-Fluoro-2,3-dihydrobenzofuran-7-yl)-4-methyl-2-(trifluoromethyl)pentane-1,2-diol | Synthonix - Stock322.300 | C15H18F4O3 | 95.000 | CC(C)(CC(O)(CO)C(F)(F)F)c1cc(F)cc2CCOc12 | 1g | 495878459
4-(5-Fluoro-2,3-dihydrobenzofuran-7-yl)-4-methyl-2-(trifluoromethyl)pentane-1,2-diol | Synthonix - Stock | 887375-37-3322.300 | C15H18F4O3 | 95.000 | CC(C)(CC(O)(CO)C(F)(F)F)c1cc(F)cc2CCOc12 | 1g | 495878459
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Accela Chembio Inc 2 | 2'-bis(trifluoromethyl)benzidine | 25g | 341-58-2 | MFCD00190155 | 97+% | Shelf Life: 1260 Days | Light Sensitive
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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2 | 2'-bis(trifluoromethyl)benzidine | 25g | 341-58-2 | MFCD00190155 | 97+% | Shelf Life: 1260 Days | Light Sensitive
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